Dual PDE4/10A inhibition restores CREB1 function and enhances neuronal resilience in models of alzheimer's disease
Our findings demonstrate that dual PDE4/10A inhibition synergistically enhances the cAMP-PKA-CREB signaling, promoting neuroprotection and synaptic remodeling. This approach offers a promising therapeutic strategy for modifying AD pathology and restoring cognitive function.
Authors
- Ching‐Lung Cheung (ORCID: https://orcid.org/0000-0002-6233-9144)
- Pianpian Zhao (ORCID: https://orcid.org/0009-0009-1676-1748)
- Cai-Rui Liu
- Qian Yu (ORCID: https://orcid.org/0000-0003-3612-6951)
- Jia-Xuan Gu
- Wei Peng (ORCID: https://orcid.org/0009-0003-7526-1360)
- Hou‐Feng Zheng (ORCID: https://orcid.org/0000-0001-5681-8598)
- Junko Saji (ORCID: https://orcid.org/0000-0002-8807-069X)
- Xia Yao
- Haohui Fang
- Mengyuan Yang (ORCID: https://orcid.org/0000-0001-5235-5733)
- Xiaoli Rong (ORCID: https://orcid.org/0000-0002-1030-509X)
- Bin Chen (ORCID: https://orcid.org/0000-0002-8839-4029)
- Lin Bo
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Westlake University (CN)
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Changchun University of Chinese Medicine (CN)
- Columbia University (US)
- University of Hong Kong (HK)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1186/s13195-025-01869-6
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16