MX1 is a novel crucial prognostic and therapeutic target inducing chemoresistance in right-sided colon cancer: insights from machine learning-based multi-omics analysis
A prognostic model based on primary location-related genes was developed to predict prognosis and chemotherapy response in RCC. MX1 was identified as a pivotal target that promotes angiogenesis and chemoresistance, thereby providing a potential therapeutic strategy for patients with RCC.
Authors
- Yingdong Hou
- Xiaofeng Zhang (ORCID: https://orcid.org/0000-0002-8267-6658)
- Haiping Xia (ORCID: https://orcid.org/0000-0003-3372-514X)
- Chenghao Ji
- Yifeng Zhou (ORCID: https://orcid.org/0000-0003-3665-907X)
- Wencheng Kong
Institutions
- Zhejiang Chinese Medical University (CN)
- Zhejiang Institute of Mechanical and Electrical Engineering (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
Publication Details
- Journal
- Human Genomics
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1186/s40246-025-00840-8
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52