Characteristics of the immune microenvironment of endometrial cancer depending on the MMR status of the tumor
In this study, it was found that dMMR endometrial tumors are characterized by an increase in the proportion of CD8+ T lymphocytes and CD20+ B lymphocytes, which may be associated with a better response to immunotherapy. The differences in spatial distribution of CD8+ T lymphocytes and CD163+ macrophages confirmed the importance of immune cell localization for prognosis and treatment efficacy. These results highlight the need for further study of the endometrial cancer microenvironment in order to personalize therapy.
Authors
- Sergey Vladimirovich Vtorushin (ORCID: https://orcid.org/0000-0002-1195-4008)
- Л. А. Таширева (ORCID: https://orcid.org/0000-0003-2061-8417)
- D. M. Loos (ORCID: https://orcid.org/0000-0002-4098-6076)
- Anna Yu. Kalinchuk (ORCID: https://orcid.org/0000-0003-2106-3513)
- Л. А. Коломиец (ORCID: https://orcid.org/0000-0002-6854-8940)
- A. A. Maltseva (ORCID: https://orcid.org/0000-0001-8212-731X)
- E.A. Tsarenkova (ORCID: https://orcid.org/0009-0009-7955-1625)
Institutions
- Tomsk National Research Medical Center (RU)
Publication Details
- Journal
- Russian Journal of Archive of Pathology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.17116/patol20258705111
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00