Heterogeneity of ALDH1, CD133 and CD34 expression in cancer stem cells of lung adenocarcinoma
In ACL, both in the surgical material and in the A549 culture, CSCs expressing the stemness markers ALDH1, CD133 and CD34 were detected. An increase in the number of CSCs expressing the stemness markers ALDH1, CD34 and CD133 in the tumor tissue occurs with carcinoma progression. In ACL, heterogeneity of CSCs by the studied markers is noted: at early stages in patients without metastases in the lymph nodes, ALDH1+ CSCs predominate in the tumor tissue, while with the appearance of metastatic lesions of the lymph nodes, CD34+ CSC populations dominate. Quantitative heterogeneity is also observed in the A549 cell culture: the largest number was CD34+ CSCs, slightly less ALDH1+ CSCs and a minimum number of cells with CD133+ CSCs.
Authors
- Irina G. Meerovich (ORCID: https://orcid.org/0000-0001-9732-8149)
- N.V. Zharkov (ORCID: https://orcid.org/0000-0001-7183-0456)
- Е А Коган (ORCID: https://orcid.org/0000-0002-1107-3753)
- Т. А. Демура (ORCID: https://orcid.org/0000-0002-6946-6146)
- Г. А. Меерович (ORCID: https://orcid.org/0000-0002-2046-5492)
- S.T. Avraamova (ORCID: https://orcid.org/0000-0001-9704-5915)
- И. В. Решетов (ORCID: https://orcid.org/0000-0002-0909-6278)
- E.E. Shchelokova (ORCID: https://orcid.org/0000-0002-5030-0429)
- N.V. Kovyazina (ORCID: https://orcid.org/0009-0005-9889-1378)
- A.E. Kholschenkova (ORCID: https://orcid.org/0009-0001-2372-9502)
- E.A. Ermakova (ORCID: https://orcid.org/0009-0007-2269-4962)
Institutions
- Sechenov University (RU)
- Russian New University (RU)
- Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences (RU)
- Prokhorov General Physics Institute (RU)
Publication Details
- Journal
- Russian Journal of Archive of Pathology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.17116/patol20258705136
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00