Pre-pandemic disease trajectories and genetic insights into long COVID susceptibility
Disease trajectories were significantly associated with long COVID, with a sex effect, highlighting the importance of pre-pandemic disease trajectories. While no strong overall genetic correlations were found, modest polygenic associations suggest a role for shared susceptibility in nervous system and musculoskeletal disorders. From a public health perspective, identifying high-risk multimorbid individuals may inform targeted prevention and care strategies.
Authors
- Natàlia Blay (ORCID: https://orcid.org/0000-0002-7160-8529)
- Judith García‐Aymerich (ORCID: https://orcid.org/0000-0002-7097-4586)
- Xavier Farré (ORCID: https://orcid.org/0000-0001-6838-9479)
- Rafael de Cid (ORCID: https://orcid.org/0000-0003-3579-6777)
- Gemma Castaño-Vinyals
- Manolis Kogevinas
Institutions
- Universitat Pompeu Fabra (ES)
- Hospital Del Mar (ES)
- Municipal Institute for Medical Research (ES)
- Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (ES)
- Instytut Badawczy Leśnictwa (PL)
- Barcelona Institute for Global Health (ES)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Hospital del Mar Research Institute (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1186/s12916-025-04427-x
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 0.00