Transiently produced IgGs enable universal SARS-CoV-2 diagnosis and differentiation recent from past infections

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused global health concerns and led to economic losses reaching trillion dollars since 2019. Many diagnostic techniques are showing great success; for instance, nucleic acid amplification showed high specificity and sensitivity in SARS-CoV-2 infections. However, the results of these techniques can be affected by the continuous evolution of SARS-CoV-2 strains, and these techniques were not compatible with differentiating infected from vaccinated animals (DIVA). To circumvent these unfavorable outcomes, a novel strategy is imperative. In this study, we made an exciting discovery: transiently produced IgGs can be used not only for diagnosis and DIVA but also for differentiating recent infections from past infections (approximately 70 days after the occurrence of vaccination or infection). This protein-peptide hybrid microarray technique will have a positive impact on the mitigation and eradication of coronaviruses.

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Publication Details

Journal
Microbiology Spectrum
Published
2025-10-27
DOI
https://doi.org/10.1128/spectrum.00044-25
Primary Topic
SARS-CoV-2 and COVID-19 Research
Type
article
Field-Weighted Citation Impact
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article

Transiently produced IgGs enable universal SARS-CoV-2 diagnosis and differentiation recent from past infections

Liguo Zhu, Hongwei Ma, Lü Zhou, Xiaoxiao Kong et al.
Microbiology Spectrum
SARS-CoV-2 and COVID-19 Research
article

Transiently produced IgGs enable universal SARS-CoV-2 diagnosis and differentiation recent from past infections

Liguo Zhu, Hongwei Ma, Lü Zhou, Xiaoxiao Kong, Hua Tian, Jingjing Cao, Dong Chen, Xiaoyu Li, Lan Yang, Fengcai Zhu, Chuchu Li, Jingzhi Li, Qian Zhen
article en

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused global health concerns and led to economic losses reaching trillion dollars since 2019. Many diagnostic techniques are showing great success; for instance, nucleic acid amplification showed high specificity and sensitivity in SARS-CoV-2 infections. However, the results of these techniques can be affected by the continuous evolution of SARS-CoV-2 strains, and these techniques were not compatible with differentiating infected from vaccinated animals (DIVA). To circumvent these unfavorable outcomes, a novel strategy is imperative. In this study, we made an exciting discovery: transiently produced IgGs can be used not only for diagnosis and DIVA but also for differentiating recent infections from past infections (approximately 70 days after the occurrence of vaccination or infection). This protein-peptide hybrid microarray technique will have a positive impact on the mitigation and eradication of coronaviruses.

Microbiology SpectrumVol. 13(12)
University of Science and Technology of China (CN), Chinese Academy of Sciences (CN), Suzhou Institute of Nano-tech and Nano-bionics (CN), Jiangsu Provincial Center for Disease Control and Prevention (CN), Nanjing Municipal Center for Disease Control And Prevention (CN), Taiwan Centers for Disease Control (TW)
Openalex Percentile: Top 64%
SARS-CoV-2 and COVID-19 Research
DOIOpen Access PDFOpenAlex
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