Human induced pluripotent stem cell–derived cardiomyocytes improve recovery from myocardial infarction in non-human primates
The transplantation of hiPSC-CMs can effectively repair injured cardiac tissue in an NHP MI model without any adverse off-target effects. Therefore, the direct intramyocardial injection of hiPSC-CMs is a promising, effective, and safe strategy for treating MI.
Authors
- Yuehui Zhang (ORCID: https://orcid.org/0000-0001-8517-7603)
- Pengfei Zhang (ORCID: https://orcid.org/0000-0002-5598-4559)
- Jiaxian Wang (ORCID: https://orcid.org/0000-0002-3923-4512)
- Qian Wang (ORCID: https://orcid.org/0000-0002-2536-7533)
- He Zhang (ORCID: https://orcid.org/0000-0002-4572-8420)
- Hang Zhang (ORCID: https://orcid.org/0000-0002-5479-3435)
- Ling Gao (ORCID: https://orcid.org/0000-0002-6391-6724)
- Yunfan Zhang (ORCID: https://orcid.org/0009-0004-6033-6179)
- Dongjin Wang (ORCID: https://orcid.org/0009-0000-3871-3100)
- Xijie Wang (ORCID: https://orcid.org/0000-0002-2035-4311)
- Wanxiang Jiang (ORCID: https://orcid.org/0000-0003-2752-179X)
- Xumin Guan (ORCID: https://orcid.org/0000-0002-7884-0849)
- Yanxia Wu
Institutions
- HELP University (MY)
- University of Macau (MO)
- Nanjing Drum Tower Hospital (CN)
- Hanby Environmental (United States) (US)
- Shanghai East Hospital (CN)
- Green Technology (US)
- Shanghai Institute of Pharmaceutical Industry (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1186/s13287-025-04664-0
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China