Self-reported physical activity and risk of primary knee replacement for osteoarthritis: a competing risks cohort analysis
The association between baseline self‑reported PA and OA‑KR depends on radiographic severity. For individuals with KL grade 2, moderate PA was associated with lower KR risk; for KL grade > 2, moderate PA was associated with higher KR risk. Clinically, PA advice may be framed by severity: encourage moderate-intensity, low-impact activity and strength/neuromuscular training in earlier disease, and emphasize load management (low-impact modes, pacing, symptom monitoring) and weight management in advanced disease within shared decision-making. Because PASE is self‑reported and measured once, causal inference is limited; longitudinal and wearable‑based assessments are needed.
Authors
- Dongning Liu (ORCID: https://orcid.org/0000-0003-1391-4066)
- Hao Peng (ORCID: https://orcid.org/0000-0001-7336-4575)
- Kai Fu (ORCID: https://orcid.org/0000-0002-8721-0734)
- Vicky Duong (ORCID: https://orcid.org/0000-0002-4450-8194)
- Win Min Oo (ORCID: https://orcid.org/0000-0002-4065-7395)
- Qianying Cai (ORCID: https://orcid.org/0000-0002-9187-8315)
- Changqing Zhang (ORCID: https://orcid.org/0000-0002-7408-4126)
- Yongqiang Zheng
- David J. Hunter
Institutions
- The University of Sydney (AU)
- Shanghai Jiao Tong University (CN)
- Royal North Shore Hospital (AU)
- University of Medicine Mandalay (MM)
- Shenzhen Sixth People's Hospital (CN)
- ShenZhen People’s Hospital (CN)
- Institute for Musculoskeletal Health (AU)
- The 180th Hospital of PLA (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- BMC Musculoskeletal Disorders
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1186/s12891-025-09254-y
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China