Importance of confirmatory test characteristics in optimizing community-based screening for tuberculosis: an epidemiological modeling analysis
Due to greater detection of individuals with high bacillary load, making confirmatory tests for community-based TB screening less expensive and more accessible may lead to greater population health benefits than further increasing test sensitivity. Nonetheless, achieving large (> 20%) increases in the health impact of ACF will require improvements to components of ACF other than the confirmatory diagnostic test.
Authors
- Adithya Cattamanchi
- Claudia Maria Denkinger (ORCID: https://orcid.org/0000-0002-7216-7067)
- Devasahayam Jesudas Christopher (ORCID: https://orcid.org/0000-0002-9405-8494)
- Florian M. Marx (ORCID: https://orcid.org/0000-0003-4630-4598)
- William O. Worodria (ORCID: https://orcid.org/0000-0002-8531-5567)
- Lukas E. Brümmer
- Theresa Ryckman (ORCID: https://orcid.org/0000-0003-3214-3228)
- David W. Dowdy (ORCID: https://orcid.org/0000-0003-0481-7475)
- Sourya Shrestha (ORCID: https://orcid.org/0000-0002-6106-6834)
- Emily A. Kendall (ORCID: https://orcid.org/0000-0002-0083-422X)
Institutions
- South African Medical Research Council (ZA)
- Johns Hopkins University (US)
- Christian Medical College, Vellore (IN)
- University of California, San Francisco (US)
- University of California, Irvine (US)
- Heidelberg University (DE)
- Stellenbosch University (ZA)
- Johns Hopkins Medicine (US)
- Mulago Hospital (UG)
- University Hospital Heidelberg (DE)
- German Center for Infection Research (DE)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1186/s12879-025-11905-3
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Else Kröner-Fresenius-Stiftung