Total Retinal Pigment Epithelium Thickness and Reflectivity, in Relation to Histology and Vision, at the Aging-AMD Transition: ALSTAR2 Baseline
Reduced TRPET and TNRR in AMD and their correlation with RMDA are statistically significant due to the large sample. Whether they have practical utility for AMD detection will be learned from ongoing longitudinal studies. In ALSTAR2, non-RPE layers may contribute to delayed RMDA.
Authors
- Christine A. Curcio (ORCID: https://orcid.org/0000-0001-9769-1538)
- Maryam Ashrafkhorasani (ORCID: https://orcid.org/0000-0003-2046-5633)
- Abbas Habibi (ORCID: https://orcid.org/0000-0002-9557-5557)
- Ziyuan Chris Wang
- Cynthia Owsley (ORCID: https://orcid.org/0000-0003-3424-011X)
- Zubin Mishra
- Zhihong Hu (ORCID: https://orcid.org/0000-0001-8307-0298)
- Muneeswar Gupta Nittala (ORCID: https://orcid.org/0000-0002-3802-6594)
- Mark E. Clark (ORCID: https://orcid.org/0000-0002-5660-2153)
- Sohaib Fasih‐Ahmad (ORCID: https://orcid.org/0009-0005-0155-0287)
- Charles Vatanatham
- Rouzbeh Abbasgholizadeh (ORCID: https://orcid.org/0000-0001-7394-000X)
- Lukas Goerdt (ORCID: https://orcid.org/0000-0002-6970-0940)
- Mehdi Emamverdi
- Gerald McGwin
- Liyan Gao
- SriniVas R. Sadda (ORCID: https://orcid.org/0000-0002-4939-3306)
- Puja Reddy Chinasigari
Institutions
- University of California, Los Angeles (US)
- University Hospital Bonn (DE)
- University of Alabama at Birmingham (US)
- Doheny Eye Institute (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1167/iovs.66.13.42
- Citations
- 3
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.12
Funders
- EyeSight Foundation of Alabama
- Research to Prevent Blindness
- Apellis Pharmaceuticals
- Bayer HealthCare
- Deutsche Forschungsgemeinschaft
- Astellas Pharma
- Heidelberg Engineering
- National Institutes of Health
- Genentech
- Novartis Pharma