The clinical and cost-effectiveness of sertraline in preventing depression in adults following a traumatic brain injury (STOP-D): study protocol for a multi-centre randomised controlled trial
This study is registered in the European Union Drug Regulating Authorities Clinical Trials Database (EudraCT no. 2022-000072-18, date: 7 January 2022) and the ISRCTN - The UK's Clinical Study Registry (ISRCTN no. 17518945, date: 23 December 2022, https://www.isrctn.com/ISRCTN17518945 ).
Authors
- David Okai (ORCID: https://orcid.org/0000-0002-0298-2031)
- Meredith Martyn (ORCID: https://orcid.org/0000-0002-2342-6771)
- Vanessa Raymont (ORCID: https://orcid.org/0000-0001-8238-4279)
- Barbara Barrett (ORCID: https://orcid.org/0000-0002-0270-6256)
- Brent Elliott
- Damian Holliman (ORCID: https://orcid.org/0000-0002-9661-1150)
- Jurate Wall
- James Paul (ORCID: https://orcid.org/0000-0001-7367-5816)
- Aminul I. Ahmed (ORCID: https://orcid.org/0000-0001-6670-0438)
- Nancy L. Parks (ORCID: https://orcid.org/0000-0003-2287-8597)
- Khalida Ismail (ORCID: https://orcid.org/0000-0001-6084-449X)
- Sue Leung
- Damien Longson (ORCID: https://orcid.org/0000-0002-3072-1023)
- Gayathri Venkatesan
- Michael Dilley
- Richard Emsley (ORCID: https://orcid.org/0000-0002-1218-675X)
- Nicholas Beckley‐Hoelscher
- Christopher Uff (ORCID: https://orcid.org/0000-0001-9787-8001)
- Alex Novak (ORCID: https://orcid.org/0000-0002-5880-8235)
- Daniel Holsgrove
- Jennifer Burgess (ORCID: https://orcid.org/0000-0003-4496-1244)
- Mark H. Wilson (ORCID: https://orcid.org/0000-0002-2346-4911)
- Frazer O’Brien
- Akshay Nair (ORCID: https://orcid.org/0000-0002-5239-7316)
- David N. Taylor
Institutions
- Greater Manchester Mental Health NHS Foundation Trust (GB)
- King's College London (GB)
- Cumbria Northumberland Tyne and Wear NHS Foundation Trust (GB)
- Manchester Academic Health Science Centre (GB)
- Warneford Hospital (GB)
- University of Oxford (GB)
- King's College Hospital (GB)
- Newcastle University (GB)
Publication Details
- Journal
- Trials
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1186/s13063-025-09027-x
- Citations
- 1
- Primary Topic
- Traumatic Brain Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- United Kingdom Clinical Research Collaboration
- National Institute for Health and Care Research
- King's Health Partners
- NIHR Maudsley Biomedical Research Centre