Water mimicry enables the formation of a solid solution of caffeine and theophylline sulphate and a new type of non-stoichiometric hydrate
Crystallization water enables the formation of a solid solution between theophylline and caffeine and affects the skin permeability of APIs.
Authors
- Beatrice Perissutti (ORCID: https://orcid.org/0000-0002-5766-4014)
- Dario Voinovich (ORCID: https://orcid.org/0000-0003-3830-8038)
- Daniel O’Nolan (ORCID: https://orcid.org/0000-0003-1798-3704)
- Matteo Lusi
- Chiara Cappuccino (ORCID: https://orcid.org/0000-0002-6543-5027)
- Greta Camilla Magnano (ORCID: https://orcid.org/0000-0002-8599-5937)
- Enrico Spoletti
- Ricardo Albarran Velo
- Lilia Croitor
Institutions
- University of Trieste (IT)
- University of Limerick (IE)
Publication Details
- Journal
- RSC Pharmaceutics
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1039/d5pm00149h
- Primary Topic
- Methane Hydrates and Related Phenomena
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Boston Scientific Corporation
- University of Limerick
- Bernal Institute, University of Limerick