Sophora alopecuroides biflavones glycoside, isolated from Sophora alopecuroides, inhibits the secretion of hepatitis B virus surface antigen through direct interaction with its antigenic loop domain
Our studies reveal that SABG exhibits an antiviral activity against HBV by directly binding to the antigenic loop of surface protein, thereby impeding its secretion, which provides pharmacological evidence for the potential use of SABG as a candidate for the alternative treatment of HBV infection.
Authors
- Rong‐Mei Gao (ORCID: https://orcid.org/0009-0006-6572-5741)
- Haiyan Yan (ORCID: https://orcid.org/0009-0000-8780-2601)
- Yuhuan Li (ORCID: https://orcid.org/0000-0003-3725-3258)
- Shuo Wu (ORCID: https://orcid.org/0000-0002-9443-5704)
- Hua Huang (ORCID: https://orcid.org/0000-0001-7317-8983)
- Huiqiang Wang (ORCID: https://orcid.org/0000-0002-5956-077X)
- Yang Ge (ORCID: https://orcid.org/0000-0002-4855-6417)
- Ya Wang (ORCID: https://orcid.org/0000-0001-5375-3901)
- Kun Wang (ORCID: https://orcid.org/0000-0003-2513-768X)
- Lijun Qiao (ORCID: https://orcid.org/0000-0002-9860-9046)
- Linlin Wang (ORCID: https://orcid.org/0000-0001-8634-5357)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Xinjiang Institute of Materia Medica (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1186/s12985-025-02970-w
- Primary Topic
- Bioactive natural compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Xinjiang
- Chinese Academy of Medical Sciences Initiative for Innovative Medicine