Translation of nervous necrosis virus involves eIF4E but not RPS6 phosphorylation and viral particle assembly in remodeled microtubule-organizing center
Our results suggest that NNV coat protein translation is initiated by p-eIF4E in VFs for 5'-cap viral RNA2 recognition, binding and later virion assembly by coat protein in the remodeled MTOC.
Authors
- Ming‐Hsien Chiang (ORCID: https://orcid.org/0000-0001-6239-2255)
- Shih‐Chieh Chen (ORCID: https://orcid.org/0000-0001-7414-4734)
- Vertika Bajpai
- Chuan-Siang Lai
- Kuei-Yuan Fang
- Chen-Hung Li
- Chien‐Wen Chen (ORCID: https://orcid.org/0000-0002-6891-3557)
- Wenya Chen (ORCID: https://orcid.org/0000-0002-3230-4514)
- Weida Chen (ORCID: https://orcid.org/0000-0002-5692-8292)
- Chi‐Yao Chang (ORCID: https://orcid.org/0000-0001-8444-0107)
- Yung‐Song Wang (ORCID: https://orcid.org/0000-0003-2871-4438)
- Chao-An Cheng
Institutions
- Fu Jen Catholic University (TW)
- National Quemoy University (TW)
- National Taiwan University (TW)
- National Tsing Hua University (TW)
- Institute of Cellular and Organismic Biology, Academia Sinica (TW)
- Chia Nan University of Pharmacy and Science (TW)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1186/s12985-025-02799-3
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00