Causal Effect of Pulmonary Hypertension on Brain Structure: A Mendelian Randomization Study Combined With Brain Magnetic Resonance Imaging
CTEPH and PAH exhibit causal associations with distinct brain regions and electrical activity, indicating a varied lung-brain axis linked to the different subtypes of PH and seemingly associated with disturbances in circulating immune cells.
Authors
- Jie Du
- Linfeng Xi (ORCID: https://orcid.org/0000-0001-5702-4159)
- Min Liu (ORCID: https://orcid.org/0000-0002-4103-8369)
- Jianping Wang (ORCID: https://orcid.org/0000-0003-4053-4480)
- Hongyi Wang (ORCID: https://orcid.org/0000-0002-1076-1140)
- Anqi Liu (ORCID: https://orcid.org/0000-0002-9432-4836)
- Yifei Ni
- Peiyao Zhang (ORCID: https://orcid.org/0000-0003-3422-0100)
- Shuai Zhang (ORCID: https://orcid.org/0009-0008-1606-5243)
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- Peking Union Medical College Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
Publication Details
- Journal
- Cureus
- Published
- 2025-10-27
- DOI
- https://doi.org/10.7759/cureus.95493
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00