Abnormal myelin could be a mediator of childhood-trauma-induced depression: A quantitative synthetic MRI study
Our findings suggest that reduced myelin content in the left lateral area 5 and left ventral dysgranular and granular insula, due to childhood trauma, mediated 6.4% to 8.1% of the variance of MDD. However, the cross-sectional design limits causal inference, and the influence of comorbid anxiety was not controlled.
Authors
- Mingxuan Gao
- Z. Li (ORCID: https://orcid.org/0000-0002-3390-2233)
- Yanyu Hao
- Shanshan Yang (ORCID: https://orcid.org/0000-0003-0549-9325)
- Shuqiong Zheng (ORCID: https://orcid.org/0000-0003-2974-441X)
- Ying Guo (ORCID: https://orcid.org/0000-0002-1299-2233)
- Jingwen Luo
- Linlin Jing (ORCID: https://orcid.org/0000-0002-9234-8850)
- Liya Gong (ORCID: https://orcid.org/0009-0002-1875-9982)
- Zhimin Chen (ORCID: https://orcid.org/0000-0002-5160-7502)
- Junyan Wen (ORCID: https://orcid.org/0000-0003-1239-234X)
- Zhikai Wu
- Ge Wen (ORCID: https://orcid.org/0000-0002-4805-8952)
- Wei Cui (ORCID: https://orcid.org/0000-0002-3697-0733)
- Honglei Yin (ORCID: https://orcid.org/0000-0002-5872-9465)
- Xuecong Lin
- Liaoming Gao
Institutions
- Third Affiliated Hospital of Southern Medical University (CN)
- Nanfang Hospital (CN)
- TCM-Intigrated Cancer Center of Southern Medical University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- NeuroImage Clinical
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.nicl.2025.103890
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00