Elucidating artemisinin (ART)-heme as a biomarker for ART resistance and ATP-dependent transport of ART in Plasmodium falciparum
ART-heme adduct displayed weak antiplasmodial activity but may still serve as a biomarker for both the antiplasmodial efficacy of ART and its resistance. ART transport in P. falciparum was ATP-dependent, and inhibition of efflux transporter may be a strategy to enhance ART potency.
Authors
- Yuan Cai (ORCID: https://orcid.org/0000-0003-0026-4930)
- Zhenghui Huang (ORCID: https://orcid.org/0000-0002-5906-6966)
- Shanshan Du (ORCID: https://orcid.org/0000-0001-6889-116X)
- Kun Xu (ORCID: https://orcid.org/0000-0001-9553-3501)
- Jie Xing (ORCID: https://orcid.org/0000-0002-7911-9906)
- Hui Liu (ORCID: https://orcid.org/0000-0003-0481-2607)
- Hongchang Zhou (ORCID: https://orcid.org/0000-0002-8631-3272)
Institutions
- Shandong University (CN)
- Huzhou Normal University (CN)
- Shanghai Institute of Nutrition and Health (CN)
- Shanghai Institute of Applied Physics (CN)
Publication Details
- Journal
- Journal of Global Antimicrobial Resistance
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1016/j.jgar.2025.10.017
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00