<i>MECP2</i> Rare Variants in Boys With Central Precocious Puberty
MECP2 rare variants were identified in boys with sporadic CPP, expanding this association as previously described in girls. Our findings provide additional evidence for a role of MECP2, an epigenetic factor, in hypothalamic control of pubertal timing.
Authors
- Ana Cláudia Latronico (ORCID: https://orcid.org/0000-0001-6782-693X)
- Matthew D. Benson (ORCID: https://orcid.org/0000-0001-5910-358X)
- Sasha Howard (ORCID: https://orcid.org/0000-0002-6698-903X)
- Jordan E. Read (ORCID: https://orcid.org/0000-0001-6731-4440)
- Melissa Magnuson
- Ana Pinheiro Machado Canton (ORCID: https://orcid.org/0000-0001-8662-5412)
- Stephanie Roberts (ORCID: https://orcid.org/0000-0002-2811-1322)
- Rathika D. Shenoy (ORCID: https://orcid.org/0000-0001-7518-3604)
- Cinthia Gabriel Meireles (ORCID: https://orcid.org/0000-0002-5970-1173)
- Ursula B. Kaiser (ORCID: https://orcid.org/0000-0002-8237-0704)
- Rona S. Carroll (ORCID: https://orcid.org/0000-0002-6804-7177)
- Jacobo Buelvas Mebarak (ORCID: https://orcid.org/0009-0003-2174-4260)
- Ana Paula Abreu (ORCID: https://orcid.org/0000-0002-5505-0852)
Institutions
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Harvard University (US)
- University of Miami (US)
- Queen Mary University of London (GB)
- Universidade de São Paulo (BR)
- Nemours Children's Health System (US)
- William Harvey Research Institute (GB)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1210/clinem/dgaf572
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00