6.A. Round table: Personalized Prevention Roadmap for the future Healthcare (PROPHET): SRIA and implementation Roadmap

Abstract Advancements in sequencing and genotyping technologies and the integration of digital resources in healthcare have ushered in a new era of medicine. According to PROPHET “personalised prevention aims to prevent onset, progression and recurrence of diseases through the adoption of targeted interventions that consider the biological information, environmental and behavioural characteristics, socio-economic and cultural context of individuals. This should be timely, effective and equitable to maintain the best possible balance in lifetime health trajectory”. By tailoring interventions based on risk profiles at population level, personalised prevention aims to delay disease onset, enhance quality of life and ultimately reduce the economic burden on healthcare systems. Although challenges exist in clinical implementation, genomics is the most advanced, providing examples of clinical utility such as genetic testing, polygenic risk scores, and pharmacogenomics. This SRIA considers the intricacies of the personalised prevention paradigm and elucidates the reasons for its crucial integration into European healthcare systems. After reviewing the latest research and incorporating various stakeholders’ perspectives, the SRIA identifies ten key challenges, including: The broad scope of promotion and prevention; Continuous evidence synthesis system supporting personalised prevention; The PROPHET Framework implementation; Data collection and integration, and Data Infrastructure; Community Engagement and trust; Health Professionals and Policy Makers involvement; Regulatory aspects and synergy with private sector; Access, Equity and Coverage; Ethical, Legal, Social Issues; Changing behaviour. The accompanying Roadmap provides a detailed blueprint for implementing tailored preventive strategies for each individual based on the latest scientific advancements and the specific needs of each context. The Roadmap outlines key goals, priority actions, implementation timelines, expected outcomes and output indicators, responsible entities, funding sources, and synergies with other EU initiatives, providing a structured plan for integrating personalised prevention into healthcare. For the ten challenges, we have identified 56 goals and 66 actions. These actions range from creating platforms and repositories for publications in the field of personalised prevention to improve evidence and interoperability across Europe, to the dissemination of the PROPHET framework in real-world settings, to the design and implementation of educational programs for professionals and citizens, and the establishment of regulations for data sharing and standardisation of data. The actions provide a detailed outline of what needs to be accomplished, as well as the potential obstacles that may arise. Timelines and potential funding actors have been outlined. The workshop represents the first event of dissemination of SRIA and Roadmap to the public health audience in order to gather insights and to foster the awareness of decision makers. Key messages • The SRIA on personalized prevention addresses a key action of the EU Cancer Plan and outlines ten challenges, including data collection, integration, and infrastructure. • The Roadmap represents a blueprint for the SRIA implementation through 56 goals and 66 actions, directed to decision makers at national and EU level, funders and scientists overall.