The role of adiponectin and AdipoR1/AKT signaling axis in mediating diabetic corneal epithelial wound healing and sensory nerve regeneration
Our results demonstrate that ADPN promotes the corneal epithelium and nerve regeneration in diabetic mice via activation of the AdipoR1/AKT signaling axis and suppression of inflammatory responses. These findings identify ADPN as a promising therapeutic candidate for promoting corneal epithelial wound healing in diabetic conditions.
Authors
- Xiuming Jin (ORCID: https://orcid.org/0000-0001-7492-5143)
- Ning Wang (ORCID: https://orcid.org/0000-0001-5803-6346)
- Ye Wang (ORCID: https://orcid.org/0000-0002-5675-2733)
- Shuo Yang (ORCID: https://orcid.org/0000-0003-0859-2795)
- Yujie Mou
- Kelan Yuan
- Chunyang Wang (ORCID: https://orcid.org/0000-0002-9565-5952)
- Wu Yaying
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Eye and Vision
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1186/s40662-025-00458-w
- Citations
- 1
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.35