Integrated Molecular Diagnostics Unmask Legionella Pneumophila and Fungal Coinfection in an Immunocompromised Host: A Case Study of Precision Antimicrobial Stewardship
Integrated molecular diagnostics enable rapid pathogen identification in critically ill immunocompromised hosts. Multi-platform verification (isothermal amplification/dPCR/mNGS) overcomes technical limitations of single methods, while serial biomarker monitoring optimizes antimicrobial stewardship for mixed infections.
Authors
- Qianyun Deng (ORCID: https://orcid.org/0000-0003-1059-1919)
- Shuaixiao Gao
- Min Lu (ORCID: https://orcid.org/0000-0002-7818-8344)
- Yunhu Zhao (ORCID: https://orcid.org/0000-0002-3745-014X)
- Zixia Wang
- Yujing Yang (ORCID: https://orcid.org/0000-0003-4878-8063)
Institutions
- People's Government of Shaanxi Province (CN)
- Guangdong Academy of Medical Sciences (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/idr.s552347
- Primary Topic
- Legionella and Acanthamoeba research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China