Quercetin-loaded mesenchymal stem cell derived extracellular vesicles enhance ovarian function in a cyclophosphamide induced ovarian damage
Quercetin-loaded EVs derived from Wharton's jelly MSCs enhanced ovarian recovery in a CTX-induced POI model through anti-apoptotic, pro-proliferative, and antioxidant pathways. These findings suggest that intraovarian administration of EVs-QUE may represent a promising strategy for fertility preservation and warrant further investigation in long-term and translational studies.
Authors
- Zeynep Ece Utkan Korun (ORCID: https://orcid.org/0000-0002-1595-569X)
- Erkut Attar (ORCID: https://orcid.org/0000-0002-8459-2538)
- Selenay Furat Rençber (ORCID: https://orcid.org/0000-0002-0501-1679)
- Candan Altuntaş (ORCID: https://orcid.org/0000-0002-2551-1849)
- Tuğba Koldankaya (ORCID: https://orcid.org/0000-0002-4557-2905)
- Zehra Seda Halbutoğulları (ORCID: https://orcid.org/0000-0001-6810-4939)
- Yusufhan Yazır (ORCID: https://orcid.org/0000-0002-8472-0261)
- Serap Mert (ORCID: https://orcid.org/0000-0001-5939-5295)
- Ahmet Öztürk (ORCID: https://orcid.org/0000-0001-8723-9417)
Institutions
- Yeditepe University (TR)
- Kocaeli Üniversitesi (TR)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1186/s13048-025-01838-5
- Citations
- 2
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- Kocaeli Üniversitesi