Heterogenous mitochondrial ultrastructure and metabolism of human glioblastoma cells: differences between stem-like and differentiated cancer cells in response to chemotherapy
We demonstrated differences in mitochondrial ultrastructure and cellular metabolism between GSCs and differentiated GBM cells in response to temozolomide, suggesting that mitochondria play an important role in the resistance of GSCs to temozolomide. This study provides a basis for further studies addressing GSC chemotherapy resistance in the context of mitochondrial structure and function.
Authors
- Metka Novak (ORCID: https://orcid.org/0000-0002-3041-1156)
- Klementina Fon Tacer (ORCID: https://orcid.org/0000-0003-1928-7745)
- Barbara Breznik (ORCID: https://orcid.org/0000-0003-0247-5811)
- Urban Bogataj
- Cornelis J.F. Van Noorden (ORCID: https://orcid.org/0000-0002-6191-0505)
- Miloš Vittori (ORCID: https://orcid.org/0000-0001-5855-4282)
- Simona Katrin Galun
Institutions
- Texas Tech University (US)
- University of Ljubljana (SI)
- Biotechnical Educational Centre Ljubljana (SI)
- Jožef Stefan International Postgraduate School (SI)
- National Institute of Biology (SI)
- Texas Tech University Health Sciences Center (US)
- Amarillo College (US)
Publication Details
- Journal
- Radiology and Oncology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.2478/raon-2025-0056
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Texas Tech University
- European Commission
- Univerza v Ljubljani