Implementation of a hospital-wide EHR-integrated antibiotic challenge order set

We implemented an electronic health record-integrated order set to standardize direct antibiotic challenges for patients with reported antibiotic allergies across nine healthcare facilities. In the first year, 104 patients were challenged (79% oral; 39% two-step). Embedded antibiotic selection, dosage, monitoring parameters, reaction guidance, and rescue medications facilitated uptake by hospitalists and subspecialists.

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Publication Details

Journal
Antimicrobial Stewardship & Healthcare Epidemiology
Published
2025-01-01
DOI
https://doi.org/10.1017/ash.2025.10215
Primary Topic
Drug-Induced Adverse Reactions
Type
article
Field-Weighted Citation Impact
0.00

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article

Implementation of a hospital-wide EHR-integrated antibiotic challenge order set

Shivani Patel, Muhammad Yasser Alsafadi, Sheng-Hua Tsai, Natalie A. Finch et al.
Antimicrobial Stewardship & Healthcare Epidemiology
Drug-Induced Adverse Reactions
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Implementation of a hospital-wide EHR-integrated antibiotic challenge order set

Shivani Patel, Muhammad Yasser Alsafadi, Sheng-Hua Tsai, Natalie A. Finch, Wolfgang Hoffmann
article en

Abstract

We implemented an electronic health record-integrated order set to standardize direct antibiotic challenges for patients with reported antibiotic allergies across nine healthcare facilities. In the first year, 104 patients were challenged (79% oral; 39% two-step). Embedded antibiotic selection, dosage, monitoring parameters, reaction guidance, and rescue medications facilitated uptake by hospitalists and subspecialists.

Antimicrobial Stewardship & Healthcare EpidemiologyVol. 5(1)
Methodist Hospital (US)
Houston Methodist Research Institute
Openalex Percentile: Top 65%
Drug-Induced Adverse Reactions
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Implementation of a hospital-wide EHR-integrated antibiotic challenge order set — Shivani Patel, Muhammad Yasser Alsafadi, et al. · Antimicrobial Stewardship & Healthcare Epidemiology (2025) | TGRS Research Map | TGRS