Neural and somatic mechanisms driving clinical improvements in post-acute schizophrenia spectrum disorders
Our findings suggest that stimulating neuroplasticity, especially in the hippocampal formation, precuneus, and posterior cingulate gyrus, may represent a promising treatment target in post-acute schizophrenia spectrum disorders. Physical exercise therapies and other lifestyle interventions, and brain stimulation approaches reflect potential treatment candidates. Given the exploratory character of the statistical analysis performed, these findings need to be replicated in independent longitudinal imaging cohorts of patients with schizophrenia spectrum disorders.
Authors
- Lukas Roell
- Isabel Maurus (ORCID: https://orcid.org/0000-0002-6208-5180)
- Christoph Lindner (ORCID: https://orcid.org/0000-0001-5688-3146)
- Daniel Keeser (ORCID: https://orcid.org/0000-0002-0244-1024)
- Peter Falkai (ORCID: https://orcid.org/0000-0003-2873-8667)
- Andrea Schmitt (ORCID: https://orcid.org/0000-0002-5426-4023)
- Berend Malchow (ORCID: https://orcid.org/0000-0002-5707-7602)
Institutions
- Technische Hochschule Augsburg (DE)
- Universidade de São Paulo (BR)
- Universitätsmedizin Göttingen (DE)
- Max Planck Institute of Psychiatry (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- European Psychiatry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1192/j.eurpsy.2025.10129
- Citations
- 1
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- International Max Planck Research School for Environmental, Cellular and Molecular Microbiology
- University of Cambridge
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Servier
- International Max Planck Research School for Advanced Methods in Process and Systems Engineering
- H. Lundbeck A/S