Metabolic Disruption in Osteoporotic Sheep: Evaluating Vitamin D Deficiency and Cortisone Effects via Biochemical Markers
Combined ovariectomy, calcium/vitamin-D-deficient diet, and glucocorticoids produce the clearest biomarker signature and DXA loss. Assay cross-reactivity limited PTH/DKK-1/cathepsin-K measurement in sheep; we summarize DXA outcomes and expand assay limitations and future validation plans.
Authors
- Thaqif El Khassawna (ORCID: https://orcid.org/0000-0002-1187-8578)
- Christoph Biehl (ORCID: https://orcid.org/0000-0003-2981-5062)
- Vahid Jahed (ORCID: https://orcid.org/0000-0003-3834-9630)
- Judith Langenstein
- Muhammad Alzweiri
- Sabine Stötzel
- Natali Bauer
- Gero Knapp (ORCID: https://orcid.org/0000-0001-9864-547X)
- Christian Heiß (ORCID: https://orcid.org/0000-0002-9593-162X)
Institutions
- University of Jordan (JO)
- Justus-Liebig-Universität Gießen (DE)
- Biruni University (TR)
Publication Details
- Journal
- Nutrients
- Published
- 2025-10-24
- DOI
- https://doi.org/10.3390/nu17213353
- Primary Topic
- Animal Genetics and Reproduction
- Type
- article
- Field-Weighted Citation Impact
- 0.00