Platelet Hyperactivation Plays a Critical Role in Exacerbating Skin Lesions in Rats with Psoriasis and Blood Stasis Syndrome
Psoriasis with BSS rats exhibit more severe skin lesions than psoriasis rats, associated with enhanced platelet activation. Clopidogrel improved blood stasis and skin inflammation, confirming that platelet activation contributes critically to skin lesion worsening.
Authors
- Jingjing Wu (ORCID: https://orcid.org/0000-0002-1736-5271)
- Zhihong Zeng (ORCID: https://orcid.org/0000-0003-2207-9584)
- Tingyu Wang (ORCID: https://orcid.org/0000-0003-4542-3587)
- Hongyu Yue (ORCID: https://orcid.org/0000-0002-6494-1251)
- Chunlin Lei (ORCID: https://orcid.org/0000-0003-1508-0720)
- Ling Han (ORCID: https://orcid.org/0000-0002-6168-8828)
- Yue Sun (ORCID: https://orcid.org/0000-0001-6348-4549)
- Xiangxiang Pi
- Fanlu Liu (ORCID: https://orcid.org/0009-0002-6779-6640)
- H. Mo
- Li Li (ORCID: https://orcid.org/0000-0003-1802-9517)
- Haojie Su
Institutions
- Guangzhou University of Chinese Medicine (CN)
- University of Michigan (US)
- Key Laboratory of Guangdong Province (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/jir.s560634
- Citations
- 1
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.80