Photodynamic mechanistic regulation of conjugated polymers for synergistic photodynamic-chemotherapy
In this work, we report a side-chain engineering strategy to switch photodynamic pathways of poly(<i>p</i>-phenylene ethynylene) (PPE) derivatives. Neutral PPE1 lacks photosensitivity, cationic PPE2 selectively generates singlet oxygen (<sup>1</sup>O<sub>2</sub>) <i>via</i> a type-II mechanism, while zwitterionic PPE3 produces superoxide anions (O<sub>2</sub><sup>-</sup>˙) through a type-I process. Notably, side-chain functionalization concurrently modulates their platinum (Pt)-binding affinities. The resulting PPE3-Pt nanoplatform undergoes DNA-triggered Pt release, restoring ROS generation and enabling synergistic chemo-photodynamic therapy.
Authors
- Minhuan Lan (ORCID: https://orcid.org/0000-0003-0464-8886)
- Chaoyi Yao (ORCID: https://orcid.org/0000-0003-4250-5034)
- Hongyan An
- Benhua Wang (ORCID: https://orcid.org/0000-0001-9084-2209)
- Xiangzhi Song (ORCID: https://orcid.org/0000-0002-4034-6386)
- Hankun Zhang
- Hui Zheng (ORCID: https://orcid.org/0000-0002-0494-1217)
- Qiang Cheng (ORCID: https://orcid.org/0000-0002-2442-8357)
- Jinsong Han (ORCID: https://orcid.org/0000-0003-1832-2641)
Institutions
- Central South University (CN)
- China Pharmaceutical University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc05271h
- Primary Topic
- Photodynamic Therapy Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00