Palladium-catalysed asymmetric allylic alkylation of hydantoins using bench-stable chiral palladium precatalysts
Hydantoins are important heterocyclic scaffolds present in a number of pharmaceutically relevant compounds. We report here a practical, scalable and enantioselective Pd-catalyzed asymmetric allylic alkylation (Pd-AAA) approach to diversely substituted enantioenriched hydantoins. The method relies on the use of chiral bench-stable Pd-precatalysts previously developed by our groups. The synthetic utility of the method was further outlined by various successful post-modifications.
Authors
- David C. Leitch (ORCID: https://orcid.org/0000-0002-8726-3318)
- Paul G. Clark (ORCID: https://orcid.org/0000-0002-1224-5705)
- Stellios Arseniyadis (ORCID: https://orcid.org/0000-0001-6831-2631)
- Yi Ma (ORCID: https://orcid.org/0000-0003-2351-9537)
- Shiqi Liu (ORCID: https://orcid.org/0009-0008-5612-3989)
Institutions
- Queen Mary University of London (GB)
- Xiamen University (CN)
- University of Victoria (CA)
- University of Manchester (GB)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc05328e
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00