Short-Term Outcomes and Immunologic Mechanisms of Adrenocorticotropic Hormone in Infantile Epileptic Spasm Syndrome: A Multicenter Prospective Trial in Southern China
About 30% children with IESS were short-term responders to ACTH therapy. The presence of hypsarrhythmia on the pre-therapy EEG was a risk factor for short-term efficacy of ACTH administration. The CD3<sup>+</sup>CD8<sup>+</sup> T cell percentage and CD3<sup>+</sup>CD4<sup>+</sup>/CD3<sup>+</sup>CD8<sup>+</sup> ratio may exhibit a predictive capacity.
Authors
- Tian Yang (ORCID: https://orcid.org/0000-0001-9336-3406)
- Wen‐Xiong Chen (ORCID: https://orcid.org/0000-0001-9076-2006)
- Chi Hou (ORCID: https://orcid.org/0000-0002-1505-6918)
- Yanqun Chang
- Jie Yu (ORCID: https://orcid.org/0000-0002-1103-2679)
- Bingwei Peng (ORCID: https://orcid.org/0000-0003-4836-4076)
- Chao Zhuo
- Yanping Ran
- Xiaojing Li (ORCID: https://orcid.org/0000-0003-1660-3108)
- Jianwei Li (ORCID: https://orcid.org/0000-0002-4979-5559)
- Yani Zhang (ORCID: https://orcid.org/0000-0002-0222-8389)
- Kelu Zheng
- Wenxiao Wu (ORCID: https://orcid.org/0009-0002-1339-9295)
- Xiuying Wang (ORCID: https://orcid.org/0000-0001-6693-3813)
- Haixia Zhu (ORCID: https://orcid.org/0000-0001-9536-9588)
- Wenlin Wu (ORCID: https://orcid.org/0000-0002-6970-4722)
Institutions
- Guangzhou Women and Children Medical Center (CN)
- Dongguan People’s Hospital (CN)
- Guangdong Province Women and Children Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Neurology and Therapy
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1007/s40120-025-00841-8
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00