Effects of Catha edulis Extract on Atorvastatin-Induced Myotoxicity in Rats: Biochemical and Histopathological Evidence
Khat extract contributes to biochemical and histopathological changes indicative of muscle injury. When combined with atorvastatin, these effects are exacerbated, leading to pronounced myopathy and kidney damage. These findings suggest that khat use may potentiate statin-induced rhabdomyolysis and increase the risk of musculoskeletal and renal complications.
Authors
- Abdulatef Mohammed Mohammed Abbas (ORCID: https://orcid.org/0009-0007-8737-3721)
- Safia Abdulatef Abdulruhman Alrezami (ORCID: https://orcid.org/0009-0002-6549-3996)
- Butheina Abdulwalli Al-Amrani (ORCID: https://orcid.org/0009-0004-4131-509X)
Institutions
- University of Science and Technology (YE)
- Sana'a University (YE)
- Al-Razi University (YE)
Publication Details
- Journal
- Journal of Experimental Pharmacology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/jep.s555519
- Primary Topic
- Forensic Toxicology and Drug Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00