Modeling chronic periodontitis in rats: Persistent alveolar bone loss mediated by periodontal pathogens
The proposed rat model of periodontitis is well characterized and replicates human disease by sustaining colonization with viable periopathogens, leading to progressive disease with alveolar bone loss. The suggested model is straightforward, easy to establish and can be used reliably in preclinical studies.
Authors
- Maksym Skrypnyk (ORCID: https://orcid.org/0000-0002-9552-4098)
- C. F. Xu (ORCID: https://orcid.org/0000-0001-8831-3607)
- Shlomo Berkovsky (ORCID: https://orcid.org/0000-0003-2638-4121)
- Axel Spahr (ORCID: https://orcid.org/0000-0003-1714-5727)
- Thilini N. Jayasinghe (ORCID: https://orcid.org/0000-0002-3374-0916)
Institutions
- The University of Sydney (AU)
- UNSW Sydney (AU)
- Macquarie University (AU)
Publication Details
- Journal
- Animal Models and Experimental Medicine
- Published
- 2025-10-26
- DOI
- https://doi.org/10.1002/ame2.70078
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00