Achieving clinically meaningful changes in haemoglobin levels in patients with non‐transfusion‐dependent β‐thalassaemia treated with luspatercept: A post hoc analysis of the phase 2 <scp>BEYOND</scp> trial
In this post hoc analysis of the phase 2 BEYOND trial, the majority of patients with non-transfusion-dependent β-thalassaemia achieved clinically meaningful haemoglobin levels ≥10.0 g/dL and increases from baseline ≥1.0 g/dL, thresholds associated with reduced risk of morbidity and mortality and recommended as an indication and target for treatment by international management guidelines, respectively.
Authors
- Mrudula B. Glassberg (ORCID: https://orcid.org/0000-0003-1929-7775)
- Patricia Martin‐Regueira
- Luciana Moro Bueno
- John B. Porter (ORCID: https://orcid.org/0000-0003-3000-9359)
- Antonis Kattamis (ORCID: https://orcid.org/0000-0002-5178-0655)
- Khaled M. Musallam (ORCID: https://orcid.org/0000-0003-3935-903X)
- Maria Domenica Cappellini (ORCID: https://orcid.org/0000-0001-8676-6864)
- Alì Taher (ORCID: https://orcid.org/0000-0001-8515-2238)
- Loyse Felber Medlin (ORCID: https://orcid.org/0000-0001-7563-5746)
- Kefeng Wang (ORCID: https://orcid.org/0000-0003-3134-356X)
- Matthew D. Dyer
- Marta Reverte
Institutions
- University College Hospital (GB)
- University College London Hospitals NHS Foundation Trust (GB)
- Khalifa University of Science and Technology (AE)
- National and Kapodistrian University of Athens (GR)
- Cornell University (US)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Bristol-Myers Squibb (United States) (US)
- American University of Beirut Medical Center (LB)
- Bristol-Myers Squibb (United Kingdom) (GB)
- Center for Cancers and Blood Disorders (US)
- Bristol-Myers Squibb (Italy) (IT)
- Weill Cornell Medicine (US)
- University College London (GB)
- Bristol-Myers Squibb (Switzerland) (CH)
Publication Details
- Journal
- British Journal of Haematology
- Published
- 2025-10-26
- DOI
- https://doi.org/10.1111/bjh.70227
- Citations
- 1
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.63