Mendelian Randomisation Uncovers Causal Immune-Metabolic Networks in Osteoarthritis: Insights from Immune Cell and Metabolite Interactions
This study establishes for the first time a genetic-level immune-metabolic-OA causal network, demonstrating causal links between immune cells and OA and highlighting the critical mediating role of metabolites.
Authors
- Jun Yao (ORCID: https://orcid.org/0000-0001-7993-6714)
- Xifan Zheng (ORCID: https://orcid.org/0000-0002-6185-8778)
- Ke Zhang (ORCID: https://orcid.org/0000-0001-9177-8245)
- Zeming Li (ORCID: https://orcid.org/0000-0003-4683-402X)
- Chuanliang Chen (ORCID: https://orcid.org/0000-0002-3446-4423)
- Xiaorong Lu
- Xiaochong Zou (ORCID: https://orcid.org/0009-0009-4977-1686)
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Nigerian Postgraduate Medical Journal
- Published
- 2025-10-01
- DOI
- https://doi.org/10.4103/npmj.npmj_187_25
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00