Causal Link Between Thyroid Function and Female-Specific Cancers: A Bidirectional Two-Sample and Mediation Mendelian Randomization Study
The researchers established the causal relationship between thyroid function and female-specific cancers, offering novel perspectives for the early prevention and intervention of endometrial and breast cancer. Furthermore, the researchers investigated the mediating role of sex hormones in the association between hypothyroidism and these cancers, providing valuable insights for future mechanistic research.
Authors
- Zhongyan Shan (ORCID: https://orcid.org/0000-0002-2849-2380)
- Tao Tao (ORCID: https://orcid.org/0000-0002-5684-1621)
- Deping Wang (ORCID: https://orcid.org/0000-0002-8365-9147)
- Jing Li (ORCID: https://orcid.org/0000-0002-3681-4095)
- Weiping Teng (ORCID: https://orcid.org/0000-0002-6445-6192)
- Chenxi Zhang (ORCID: https://orcid.org/0000-0003-4566-9843)
- Dongdong Luo
- Bingrui Gao
Institutions
- Dalian Medical University (CN)
- Renji Hospital (CN)
- Mudanjiang Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- International Journal of Women s Health
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/ijwh.s552719
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China