Serum metabolomics-based diagnostic biomarkers for colorectal cancer: insights and multi-omics validation
This study reveals distinct serum metabolic signatures and pathway disruptions in CRC patients and presents a high-performance, minimally invasive diagnostic model based solely on metabolomics data. While the integration of methylation features offers incremental benefit, metabolomics remains the dominant predictor, underscoring its potential as a standalone platform for early CRC screening and precision medicine.
Authors
- Taorui Wang (ORCID: https://orcid.org/0009-0001-9635-4123)
- Zijun Lai
- Peng Du (ORCID: https://orcid.org/0000-0001-9355-0789)
- Shengjun Tang
- Yuanxu Gao (ORCID: https://orcid.org/0000-0001-5314-0195)
- Gen Li (ORCID: https://orcid.org/0000-0002-7298-2141)
- Zhihai Liu (ORCID: https://orcid.org/0000-0001-6743-5090)
Institutions
- Macau University of Science and Technology (MO)
- University of Macau (MO)
- Wenzhou Medical University (CN)
- Affiliated Eye Hospital of Wenzhou Medical College (CN)
- China Guangzhou Analysis and Testing Center (CN)
- Guangzhou Women and Children Medical Center (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3389/fendo.2025.1663938
- Citations
- 1
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.81