Senescent human fibroblasts have increased FasL expression and impair the tumor immune response
Our results identified the expression of FasL expression as a novel component of the senescent tumor microenvironment and highlight the importance of evaluating the impact of therapy-induced senescence in humanized models to understand and predict the outcome of cancer treatments.
Authors
- Joshua Dulong (ORCID: https://orcid.org/0000-0003-0698-3530)
- Gaël Moquin‐Beaudry (ORCID: https://orcid.org/0000-0003-3286-3188)
- Christian Beauséjour (ORCID: https://orcid.org/0000-0002-1693-5172)
- Basma Benabdallah
- Mónica Cruz-Barrera
- Anthony Sonn
- Georgio Mansour Nehmo
- Oanh Lê
Institutions
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3389/fimmu.2025.1685269
- Citations
- 2
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Cancer Research Society
- Terry Fox Foundation
- Fonds de Recherche du Québec - Santé