Effects of different opioids on the contractile tension of isolated rat intestinal smooth muscle
As the concentration increased, different opioids inhibited the contractile tone of rat intestinal smooth muscle <i>in vitro</i>. The intensity of inhibition was butorphanol > nalbuphine ≈ oxycodone > sufentanil > remifentanil, and the Contraction frequency was almost unaffected except in the very high concentration sufentanil group.
Authors
- Jianying Hu (ORCID: https://orcid.org/0000-0003-1965-7494)
- Yan Cheng (ORCID: https://orcid.org/0000-0001-7189-3991)
- Yang Chen (ORCID: https://orcid.org/0000-0003-0147-3443)
- Sun Shen
- Shaoqiang Huang
Institutions
- Fudan University (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3389/fphar.2025.1617936
- Primary Topic
- Neuropeptides and Animal Physiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00