Sex-specific metabolic effects of Treg expansion in db/db mice
Endogenous Treg expansion exerts sex-specific metabolic and anti-inflammatory benefits in db/db T2D mice, with females showing greater improvements in insulin resistance, inflammation, and hepatic lipid metabolism. These findings support Treg-based immunomodulation as a potential therapeutic approach for T2D and emphasize the need for sex-specific considerations in future research.
Authors
- Anna Álvarez-Guaita (ORCID: https://orcid.org/0000-0002-9248-2275)
- Cristina Hernández (ORCID: https://orcid.org/0000-0002-3109-1721)
- María Llorián‐Salvador (ORCID: https://orcid.org/0000-0002-1120-6579)
- David A. Pérez-Martínez (ORCID: https://orcid.org/0000-0001-5587-0415)
- Rafael Simó (ORCID: https://orcid.org/0000-0003-0475-3096)
- Lorena Ramos-Pérez
- María Jose Canz
- Elisabet Torras-Peyrotón
Institutions
- Universitat Autònoma de Barcelona (ES)
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Vall d'Hebron Institut de Recerca (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3389/fimmu.2025.1599985
- Citations
- 2
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Ministerio de Ciencia, Innovación y Universidades
- European Commission
- Generalitat de Catalunya
- Universitat Autònoma de Barcelona
- Agència de Gestió d'Ajuts Universitaris i de Recerca