Extracellular matrix stiffness regulates the proliferation and migration capacities of lymphatic endothelial cells via FAT1
Together, our study uncovers FAT1 as a pivotal mechanosensor in LECs and highlight its significance in the biomechanical regulation. Targeting the FAT1-mediated signaling pathways may serve as a novel therapeutic strategy to inhibit tumor lymphatic metastasis.
Authors
- Jian Yu (ORCID: https://orcid.org/0000-0001-8604-4538)
- Zhang-Run Xu
- Cuixia Yang (ORCID: https://orcid.org/0000-0001-6947-1706)
- Dandan Chen (ORCID: https://orcid.org/0000-0003-0926-3301)
- Yiwen Liu (ORCID: https://orcid.org/0000-0003-0455-1013)
- Feng Gao (ORCID: https://orcid.org/0000-0002-4731-3886)
- Yan Du (ORCID: https://orcid.org/0000-0002-4174-6488)
- Qian Guo (ORCID: https://orcid.org/0000-0002-5608-1458)
- Yiqing He
- Guoliang Zhang (ORCID: https://orcid.org/0009-0004-2768-4120)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3389/fcell.2025.1667154
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00