Elevated IL-6, IL-10, and IFN-γ levels in fatal elephant endotheliotropic herpesvirus – hemorrhagic disease cases suggest an excessive proinflammatory cytokine response contributes to pathogenesis
In conjunction with pathological findings, including acute systemic inflammation and multiple organ dysfunction, we propose that a pathogen-induced cytokine storm indeed underlies EEHV-HD pathogenesis, which would support investigation into the use of anti-inflammatory therapies to control disease.
Authors
- Jooske IJzer (ORCID: https://orcid.org/0000-0003-0731-1015)
- Tabitha E. Hoornweg (ORCID: https://orcid.org/0000-0001-8429-9406)
- Cornelis A. M. de Haan (ORCID: https://orcid.org/0000-0002-4459-9874)
- Monique Mulder (ORCID: https://orcid.org/0000-0003-0460-3645)
- Willem Schaftenaar (ORCID: https://orcid.org/0000-0001-5934-4914)
- Victor P. M. G. Rutten (ORCID: https://orcid.org/0000-0002-6171-1805)
- Mariska Lugtenburg
- Anne van Beest
Institutions
- University of Applied Sciences Utrecht (NL)
- Utrecht University (NL)
- Association of Zoos and Aquariums (US)
- Onderstepoort Veterinary Academic Hospital (ZA)
- University Medical Center Utrecht (NL)
- University of Pretoria (ZA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3389/fimmu.2025.1645752
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80