Differential expression of platelet CD147 in moderate altitude conditions: implications for coronary plaque stability assessment
This study identifies platelet CD147 as a promising predictor for differentiating plaque stability in CHD under moderate altitude conditions. Our findings suggest that CD147 not only contributes to platelet activation and thrombus formation but may also directly influence plaque stability. The impact of chronic hypoxia and other environmental stressors in moderate altitude regions on CD147 expression provides new insights for risk stratification and targeted therapeutic strategies in altitude-specific populations.
Authors
- Yan-Kun Shi
- Juan Lv (ORCID: https://orcid.org/0000-0001-7166-2501)
- Xin Zhang (ORCID: https://orcid.org/0000-0002-8376-617X)
- Yu Chen (ORCID: https://orcid.org/0000-0002-9452-3077)
- Yan Wang (ORCID: https://orcid.org/0009-0000-0159-972X)
- Sijie Wang (ORCID: https://orcid.org/0000-0002-0925-2365)
- Lisha Wang (ORCID: https://orcid.org/0000-0002-8889-5827)
- Lixia Yang (ORCID: https://orcid.org/0000-0002-9795-0373)
- Si Lu
- Chun-Ping Bao
- Yong Ren
- Rui-Xi Zi
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Pingjin Hospital (CN)
- Dali University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3389/fcvm.2025.1621491
- Primary Topic
- Acute Myocardial Infarction Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00