Neuroprotective mechanisms of valproic acid and alpha-lipoic acid in ALS: a network pharmacology-based investigation
VPA and ALA synergistically alleviate ALS by modulating multiple targets and activating the PI3K/AKT/FoxO3a pathway. These findings support their potential as a combinatorial therapeutic strategy for ALS.
Authors
- Wenmo Zhang
- Jing Xu (ORCID: https://orcid.org/0000-0002-5304-7350)
- Xingli Tan
- Di Huo (ORCID: https://orcid.org/0009-0005-7888-1092)
- Honglin Feng (ORCID: https://orcid.org/0000-0002-5062-8846)
- Ling Han
- Dongmei Zhang (ORCID: https://orcid.org/0000-0002-3111-8728)
- Di Wang (ORCID: https://orcid.org/0000-0002-3940-6177)
- Ming Wang (ORCID: https://orcid.org/0000-0003-1071-4472)
- Jing Wang (ORCID: https://orcid.org/0000-0002-7960-0396)
- Xiaoli Su (ORCID: https://orcid.org/0000-0003-0674-8354)
- Jiling Cheng (ORCID: https://orcid.org/0000-0002-7135-8857)
Institutions
- Hebei Medical University (CN)
- Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3389/fphar.2025.1681929
- Citations
- 1
- Primary Topic
- Biochemical Acid Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- National Natural Science Foundation of China
- Chinese Academy of Agricultural Sciences