Treatment of diabetic ulcers with Chuang Ling Ye: systems pharmacology and functional validation reveal the mechanism of angiogenesis and inflammation abatement driven by the PI3K-AKT signaling pathway
CLY promotes DU healing by attenuating inflammatory responses and enhancing angiogenesis through activation of the PI3K-Akt signaling pathway.
Authors
- Cunyu Zhang
- Yuanzi Zhou
- Gaoyuan Wang (ORCID: https://orcid.org/0000-0003-4039-748X)
- Ying Liu (ORCID: https://orcid.org/0000-0002-7205-9365)
- Xiuxian Yin (ORCID: https://orcid.org/0000-0001-5011-1188)
- Qian Wang (ORCID: https://orcid.org/0000-0002-4541-9898)
- Xiao Feng (ORCID: https://orcid.org/0000-0002-3282-5301)
- Chaoqun Ma (ORCID: https://orcid.org/0000-0002-6830-8568)
- Chao Pan (ORCID: https://orcid.org/0000-0001-9057-2878)
- Ya Zhao (ORCID: https://orcid.org/0000-0001-8696-3454)
- Yue Chen (ORCID: https://orcid.org/0000-0002-1260-4683)
- Yi Nan (ORCID: https://orcid.org/0000-0002-5511-9266)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Jiangsu Province Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3389/fphar.2025.1644541
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00