Excessive DAO inhibits myoblast migration, leading to impaired myotube fusion and muscle strength decline by reducing ECM
This study provides experimental evidence that exssive DAO impairs muscle strength by inhibiting myoblast migration and fusion via the Fbln1/FAK pathway. The findings reveal a potential regulation between different organs and cells, and highlight a novel metabolic-biomechanical uncoupling mechanism linked by DAO in sarcopenia.
Authors
- Qiyang Wang (ORCID: https://orcid.org/0000-0002-3054-4207)
- Jianchao Xue (ORCID: https://orcid.org/0000-0001-9818-9101)
- Junbo Hou (ORCID: https://orcid.org/0000-0003-1281-5162)
- Yu Zhao (ORCID: https://orcid.org/0000-0002-9592-0867)
- Yiming Liang
- Rui‐Hua Xu (ORCID: https://orcid.org/0000-0001-9771-8534)
- Sheng Lu (ORCID: https://orcid.org/0000-0003-3596-4136)
- Mu Liu (ORCID: https://orcid.org/0000-0002-1202-5673)
- Hongying Yang (ORCID: https://orcid.org/0000-0003-0246-2797)
- Zhenggang Li (ORCID: https://orcid.org/0000-0003-0109-3221)
Institutions
- Kunming University of Science and Technology (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- First People's Hospital of Yunnan Province (CN)
- Second People's Hospital of Yunnan Province (CN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3389/fbioe.2025.1606357
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Kunming University of Science and Technology