Study on Chaiyuwendan decoction’s inhibition of hippocampal neuron apoptosis to alleviating depression by activating the AKT/CREB pathway
CYWD can alleviate depression through protecting hippocampal neurons by activating the AKT-CREB signaling pathway, increasing the proportion of anti apoptotic proteins. These findings provided a valuable reference to CYWD as a promising alternative against depression.
Authors
- Penghua Lai
- Qi Liu (ORCID: https://orcid.org/0000-0002-3464-9102)
- Ruobing Liu
- Sijie Cheng (ORCID: https://orcid.org/0009-0001-1494-2862)
- Yuerong Huang
- Huiqing Liang (ORCID: https://orcid.org/0000-0003-1719-8589)
- Yan Qiu (ORCID: https://orcid.org/0000-0002-3121-1455)
- Hongli Zhuang
- Shaoliang Zhang (ORCID: https://orcid.org/0000-0002-3079-3377)
- Chunrong Li (ORCID: https://orcid.org/0000-0001-9890-8022)
- Jie Ren (ORCID: https://orcid.org/0000-0003-0105-4820)
- Shaodong Chen (ORCID: https://orcid.org/0000-0003-4727-5135)
- Jingmin Zhang (ORCID: https://orcid.org/0000-0002-9159-8399)
- Tianxiang Wang (ORCID: https://orcid.org/0000-0001-5215-830X)
- Bei Zhou (ORCID: https://orcid.org/0000-0002-7473-7174)
- Liuyi Wang
Institutions
- Beijing University of Chinese Medicine (CN)
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Xiamen University Malaysia (MY)
- Xiamen Chang Gung Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3389/fphar.2025.1610899
- Primary Topic
- Medicinal Plants and Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province