Lactylation-Related Gene CALM1 Promotes Aortic Dissection via Immune Microenvironment Remodeling: Insights from Bioinformatics and Clinical Evidence
Our study unveils significant differences in lactylation levels within the immune cells of aortic tissue between AD patients and healthy individuals. Moreover, we provide experimental validation that the lactylation-related gene CALM1 may serve as a promising biomarker for the diagnosis of AD, offering new insights into the pathogenesis and potential diagnostic approaches for this deadly condition.
Authors
- Weizhang Xiao (ORCID: https://orcid.org/0000-0003-0069-3735)
- Xiaoyu Qian (ORCID: https://orcid.org/0000-0001-6954-1022)
- Zhen Zhu (ORCID: https://orcid.org/0000-0002-7040-9288)
- Zhi‐Ming Yu (ORCID: https://orcid.org/0000-0002-7186-2543)
- Qun Xue (ORCID: https://orcid.org/0000-0003-1011-1284)
- Xuesong Zhang (ORCID: https://orcid.org/0000-0002-0723-6900)
- Yue Pan (ORCID: https://orcid.org/0009-0000-9458-7110)
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/jir.s539938
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00