CTRP6 as a negative regulator of anti-inflammatory M2 macrophage polarization
Since endogenous CTRP6 expression in BMDMs is upregulated by M1 polarization inducers, it may further hinder inflammation resolution, even in the presence of IL-4 during tissue repair, establishing it as a key driver of adipose tissue inflammation in obesity.
Authors
- Dingbo Lin (ORCID: https://orcid.org/0000-0002-7441-8210)
- Jyotsna Kumar
- Muhammad Zubair Mehboob (ORCID: https://orcid.org/0000-0002-5659-5192)
- Xia Lei (ORCID: https://orcid.org/0000-0003-4241-6576)
- Emma Kempton
Institutions
- Oklahoma State University (US)
Publication Details
- Journal
- Immunometabolism
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1097/in9.0000000000000070
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Oklahoma State University
- Johns Hopkins University
- Higher Education Commision, Pakistan
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases