ACLY facilitates alanine flux in the livers of db/db mice: a hyperpolarized [1-13C]pyruvate MRS study
Together, these findings support a model in which ACLY facilitates amino acid-driven gluconeogenesis through metabolic control of ALT-mediated transamination, consistent with increased pyruvate-alanine exchange. Hyperpolarized [1-<sup>13</sup>C]pyruvate MRS thereby provides a sensitive, translational readout of dynamic hepatic metabolism relevant to NAFLD and T2DM.
Authors
- Jae Eun Song (ORCID: https://orcid.org/0000-0002-7616-543X)
- Soobin Lim (ORCID: https://orcid.org/0000-0001-9062-9758)
- Ho‐Taek Song (ORCID: https://orcid.org/0000-0002-6655-2575)
- Young‐Suk Choi (ORCID: https://orcid.org/0000-0003-4930-8455)
Institutions
- Yonsei University (KR)
- Seoul National University Hospital (KR)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3389/fendo.2025.1663958
- Primary Topic
- Advanced NMR Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Yonsei University
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea
- Yonsei University College of Medicine