Development and validation of a novel scoring system integrating MIBG scintigraphy and SPECT imaging for differentiating Parkinson’s disease

A combination of MIBG scintigraphy parameters and SPECT imaging provides good diagnostic accuracy for differentiating PD from PS. The developed logistic regression model and the simplified scoring system offer promising tools for clinical practice, potentially improving diagnostic precision. Further prospective validation in larger, diverse cohorts is warranted.